SPRAVATO VS. KETAMINE



doctor giving lady an infusions

Ketamine Infusions


Ketamine infusions are a reliable treatment for Major Depressive Disorder (MDD) and have been proven to be a successful treatment option for 70% of treatment resistant patients. They have been the subject of extensive research for over the last 17 years. Its high success rate and lack of side effects makes it the most promising treatment for the tens of millions of people who cannot find relief from standard anti-depressants, like SSRIs, and therapy.  Learn more about Ketamine infusions from our links below. 

About Ketamine

Ketamine FAQ’s

Ketamine Research



Spravato logo

Spravato™ – Esketamine Nasal Spray


Due to the success Ketamine have had in treating Major Depressive Disorder (MDD), it was inevitable that a version of it would be created for FDA approval. Because Ketamine is a generic drug that cannot be patented, pharmaceutical companies explored small variations of the Ketamine molecule that could also be effective for treating depression.

In 2019, the Esketamine nasal spray Spravato™ was approved by the FDA for the treatment of MDD that is treatment resistant or includes suicidal thoughts. With its approval, patients now have the choice between Ketamine IV infusions and esketamine nasal spray for their treatment of MDD. 



Spravato nasal spray

What is the Difference Between Ketamine and Esketamine?


There are two different types of Ketamine: R-Ketamine and S-Ketamine. While they are nearly identical molecules, they have slightly different effects on the brain. The type of Ketamine used in IV infusions is racemic, which means that is a mixture of R-Ketamine and S-Ketamine. Esketamine is isolated to only contain S-Ketamine, which makes Spravato unique.

Early scientific evidence suggests that while both are effective treatments, but IV Ketamine infusions of racemic Ketamine may present better outcomes. Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.” (Journal of Affective Disorders) 




Comparison of IV Ketamine Infusions vs Spravato™


 Ketamine IV Infusions Spravato™
Method of Delivery Ketamine is given through an IV over 40 minutes precisely. This allows the provider exact control of the experience and enhance the cognitive effects of the treatment. Spravato™ is self-administered in two to three intranasal sprays admin in five-minute increments. An alternative for patients who would prefer to avoid an IV.
Insurance Coverage Insurance reimbursement for IV treatments is increasingly common but not guaranteed. Payments are made up front and submitted for reimbursement. Your insurance may cover the cost of Spravato™. Prior approval will be established before treatment.
Your responsibility could be as little as $10 for each dose.
Bioavailability The bioavailability of IV ketamine is 100%.
This means the full dose that is given will reach the brain.
Nasal spray of applications has a bioavailability of approximately 50%.
Spray can remain in the nasal passages and be swallowed, which the affects the amount of medication that reaches the brain.
Treatment Schedule Six Ketamine infusions are administered over the course of 2-3 weeks.

Maintenance booster infusions are needed by many patients. The frequency depends on the strength and length of the patient’s response. The schedule varies from once a month to two times a year.
Weeks 1 to 4: Spravato ™ is administered twice a week, eight times.

Weeks 5 to 8: One treatment weekly

Week 9 and after: Every 2 weeks or once weekly, depending whether 2 weeks provides enough response.
Dosage IV dose is determined by weight (Kg/Kilograms) and titrated to provide a consistent, controlled, and comfortable delivery. Spravato™ is provided in two doses: 56mg and 84mg.

The prescribing health care provider will select the dose based on the patient’s treatment response.
Eligible Disorders Treated Major Depressive Disorder
All Types of Treatment Resistant Depression
PTSD
Anxiety Disorders
Bipolar Disorder
Substance Abuse
Neuropathic Pain
FDA Approved for Major Depressive Disorder
Medication Requirements Treatments can be given by themselves without any other medications or while taking any psychiatric medication Spravato™ must be administered in combination with an oral antidepressant.
Length of Treatment Between 75 and 90 Minutes A minimum of 2 hours after initial dose is taken


pathway to beach

Why Choose New Pathways Clinic for Your Spravato Treatments?


Nora Finnegan has 10 years of experience treating treatment resistant patients with Ketamine and she is ready to help guide you through your Esketamine Spravato treatments. With a simple nasal spray application, Spravato offers patients another option for treating their major depressive disorder and suicidal ideation.

Do anti-depressants feel like they are merely treating surface level symptoms?

Have anti-depression medications and counseling left you feeling like no treatment works for you? 

Schedule a free consultation with the experienced team at New Pathways Clinic and see if Spravato could help you.



STILL HAVE QUESTIONS?


Check out the Spravato FAQ’s or learn more about us here.
Also, feel free to contact us anytime with any questions you may have.


FREE CONSULTATIONCONTACT US

Keep In Touch

NP-Logo-White-footer

Our mission is to create a holistic mental wellness campus for Cleveland, combining cutting edge treatments like ketamine infusions with health professionals specialized in providing accompanying therapy and lifestyle education. We strive to grow and adapt as the scientific body of research continues to expand and diversify for mental health treatments to lead Cleveland into the future.