Semaglutide and Tirzepatide Weight Loss Shots: FAQs



Please click the boxes to the right of each question below to learn the answers to these FAQs on Semaglutide and Tirzepatide.


  • What are Semaglutide and Tirzepatide?
  • What conditions are Semaglutide and Tirzepatide used to treat?
  • How does Semaglutide and Tirzepatide work for weight loss?
  • What’s the difference between Semaglutide and Tirzepatide?
  • Are there side effects to these drugs to be aware of?
  • Is Semaglutide or Tirzepatide addictive?
  • Once one loses weight with one of these drugs, do they need to remain on them permanently to keep the weight off?
  • Can one overdose on Semaglutide or Tirzepatide weight loss shots?
  • It’s been said that these drugs were originally designed to help those with Diabetes. Am I taking the drug away from someone with Diabetes by using it at New Pathways Clinic?
  • Are Semaglutide and Tirzepatide weight loss shots available over the counter?
  • Can Semaglutide or Tirzepatide be used in combination with other medications?
  • How long does it take for Semaglutide and Tirzepatide to start working?
  • Are there any dietary restrictions or considerations while taking Semaglutide or Tirzepatide?
  • Can Semaglutide or Tirzepatide be used during pregnancy or while breastfeeding?
  • What is the recommended dosage and duration of treatment for Semaglutide and Tirzepatide?
What are Semaglutide and Tirzepatide?

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that mimics the action of the natural hormone GLP-1 in the body. GLP-1 is released by the intestines in response to food intake and helps regulate blood sugar levels by stimulating insulin release and reducing glucagon secretion. Semaglutide is administered as an injectable medication.

Tirzepatide is another GLP-1 RA, but it also has a dual action as it simultaneously acts on the glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP is another hormone involved in regulating blood sugar levels after eating. By targeting both GLP-1 and GIP receptors, tirzepatide is designed to provide more potent blood sugar control.

What conditions are Semaglutide and Tirzepatide used to treat?

We only prescribe Semaglutide and Tirzepatide for weight loss. However, they both are also used to improve glycemic control in adults with type 2 diabetes. Semaglutide is also being studied off-label for alcohol addiction and inflammatory conditions.

How does Semaglutide and Tirzepatide work for weight loss?

Semaglutide and Tirzepatide both produce amazing weight loss results by moderating your digestive process and cravings. Specifically, they are responsible for the following effects:

  1. Increased sensation of feeling full: Semaglutide acts on the GLP-1 receptors in the brain, specifically the hypothalamus, which regulates appetite and feelings of satiety. By activating these receptors, semaglutide induces a sense of fullness, leading to reduced appetite and decreased food intake.
  2. Slower Gastric Emptying: GLP-1 receptor agonists like semaglutide also slow down the rate at which the stomach empties its contents into the small intestine. This delay in gastric emptying can contribute to increased feelings of fullness and prolonged satisfaction after eating, further reducing food consumption.
  3. Reduced Caloric Intake: The combination of increased satiety and slowed gastric emptying results in a decreased desire to eat, and a lower intake of calories overall.
  4. Weight Set Point Regulation: Semaglutide may also have an impact on the body’s weight set point—the weight range that the body tends to maintain. By influencing the body’s regulatory systems, semaglutide helps shift the weight set point to a lower level, making it easier for some individuals to lose weight and maintain the new lower weight.
What’s the difference between Semaglutide and Tirzepatide?

They are very similar drugs, used for the same conditions. Tirzepatide is a newer and slightly more effective GLP-1 for weight loss. However, it is also more expensive. We generally recommend patients start on Semaglutide to save money. If Patients max-out on their Semaglutide dosing and have not yet reached their target weight, we will recommend switching to Tirzepatide.

Are there side effects to these drugs to be aware of?

Semaglutide, like any medication, may cause side effects in some individuals. The side effects can vary from person to person, and not everyone will experience them. These side effects are usually mild and may improve over time as the body adjusts to the medication. We also can provide additional medications to treat them.
Common side effects of semaglutide may include:

  1. Nausea
  2. Vomiting
  3. Diarrhea
  4. Abdominal pain or discomfort
  5. Loss of appetite
  6. Headache
  7. Fatigue
  8. Constipation
Is Semaglutide or Tirzepatide addictive?

No, there is no evidence to suggest that Semaglutide or Tirzepatide are addictive. Semaglutide and Tirzepatide are not classified as addictive substances, nor do they have any known properties that would lead to addiction or dependence.

Once one loses weight with one of these drugs, do they need to remain on them permanently to keep the weight off?

Weight loss is a complex process influenced by various factors, including genetics, lifestyle, and individual metabolism. For many people, maintaining weight loss over the long term can be challenging, regardless of the method used to achieve it – whether through lifestyle changes, medication, or other interventions.
When considering the use of Semaglutide for weight loss, it’s essential to work closely with a healthcare professional who can provide guidance and support throughout the weight loss journey. They can help design a comprehensive plan that includes not only the use of medication but also lifestyle changes, such as adopting a balanced diet, increasing physical activity, and establishing healthy habits.

Can one overdose on Semaglutide or Tirzepatide weight loss shots?

Yes, both Semaglutide and Tirzepatide can cause overdose if taken in excessive amounts. These medications are prescribed at specific doses based on individual needs and medical conditions. Taking more than the prescribed dose can lead to serious health consequences such as:

  • Severe nausea and vomiting
  • Severe diarrhea
  • Low blood sugar (hypoglycemia)
  • Dehydration
  • Dizziness or lightheadedness
  • Rapid heart rate (tachycardia)
  • Severe abdominal pain

If you suspect an overdose or experience any concerning symptoms after taking Semaglutide or Tirzepatide, seek immediate medical attention or visit the nearest emergency room.

It’s been said that these drugs were originally designed to help those with Diabetes. Am I taking the drug away from someone with Diabetes by using it at New Pathways Clinic?

No, Semaglutide and Tirzepatide are used off-label for weight loss and are provided by a special pharmacy that distributes from a separate supply than what is prescribed to patients with diabetes. The brand name version of Semaglutide – Ozempic – is prescribed for people with diabetes.

Are Semaglutide and Tirzepatide weight loss shots available over the counter?

No, neither semaglutide nor tirzepatide was available over the counter. Both medications are prescription drugs, meaning you cannot obtain them without a valid prescription from a licensed healthcare provider.

Can Semaglutide or Tirzepatide be used in combination with other medications?

Yes. Semaglutide and Tirzepatide are generally safe to use in combination with almost all other medications. They can also be combined with other appetite suppressants for maximum effects. Always inform your healthcare provider about any medications, supplements, or herbal products you are taking before starting Semaglutide, Tirzepatide, or any new medication.

How long does it take for Semaglutide and Tirzepatide to start working?

They both work extremely quickly! The effects on the moderation of appetite and digestion will be noticed within hours of receiving the injection. The average amount of weight a patient loses in the first month is around 10lbs. If your appetite is unchanged, you may need a higher dose to get the desired results.

Are there any dietary restrictions or considerations while taking Semaglutide or Tirzepatide?

There are no dietary restrictions but we encourage a healthy, well-balanced diet while being on Semaglutide and Tirzepatide. While you do not need to regulate which types of food you eat on these drugs, there are some considerations for how you eat. We would recommend the following:

  1. Consistent Meal Timing: Both Semaglutide and Tirzepatide are GLP-1 receptor agonists, which can affect how the body responds to food. It’s important to have regular meal times and not skip meals, as this can help maintain stable blood sugar levels and minimize the risk of hypoglycemia.
  2. Balanced Meals: Aim for balanced meals that include a variety of nutrient-rich foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats. A balanced diet can help support overall health and provide essential nutrients.
  3. Carbohydrate Intake: Carbohydrates can significantly impact blood sugar levels. Work with your healthcare provider or a registered dietitian to determine an appropriate carbohydrate intake that matches your individual needs and medication regimen.
  4. Avoid Skipping Medications: Take Semaglutide or Tirzepatide as prescribed by your healthcare provider. Skipping doses may lead to fluctuating blood sugar levels.
  5. Alcohol Intake: Be cautious with alcohol consumption, as it can affect blood sugar levels and may interact with certain diabetes medications. Discuss alcohol consumption with your healthcare provider to determine what is safe and appropriate for you.
  6. Monitor Blood Sugar Levels: Regularly monitor your blood sugar levels as advised by your healthcare provider. This can help you and your doctor make necessary adjustments to your medication and dietary plan as needed.
  7. Hydration: Stay adequately hydrated by drinking plenty of water throughout the day. Dehydration can affect blood sugar levels, so it’s important to drink fluids regularly.
Can Semaglutide or Tirzepatide be used during pregnancy or while breastfeeding?

Semaglutide and Tirzepatide are not recommended for use during pregnancy or while breastfeeding. Both medications are pregnancy category B, which means there may be some animal studies showing no risk to the fetus, but there are no adequate and well-controlled studies in pregnant women.
It’s essential for pregnant or breastfeeding individuals to work closely with their healthcare providers to manage their condition safely. During pregnancy, blood sugar control is crucial for both the health of the mother and for the developing baby and thus it is not recommended, since both drugs affect blood sugar levels.

What is the recommended dosage and duration of treatment for Semaglutide and Tirzepatide?

The duration of and dosage of treatment with Semaglutide and Tirzepatide may vary based on individual health factors as well as the response to the medication. You can work closely with our medical staff to ensure that the treatment plan is tailored to your specific health needs and goals.



At New Pathways Clinic our heartfelt mission is to establish a holistic mental wellness campus that touches the lives of individuals in the greater Cleveland and Columbus regions. We are dedicated to combining state-of-the-art mental health treatments, like Ketamine infusions and Spravato nasal spray with the expertise of compassionate mental health professionals to treat depression, anxiety, PTSD, and bipolar disorder.

Our unwavering commitment drives us to continuously evolve and adapt as the scientific landscape of ketamine research expands and diversifies, leading to innovative mental health treatments. We are determined to pave the way for a healthier future for Cleveland and central Ohio. 

New Pathways Clinic also offers NAD+ infusions for longevity and health, Semaglutide & Tirzepatide weight-loss shots, and medication management for psychiatric medications.

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